Phase II Study of Continuous Venous Infusion of 5-Fluorouracil in Advanced Pancreatic Cancer
- 1 January 1991
- journal article
- clinical trial
- Published by S. Karger AG in Oncology
- Vol. 48 (1) , 18-21
- https://doi.org/10.1159/000226887
Abstract
Continuous venous infusion of 5-fluorouracil (5FU) was investigated in 18 patients with measurable advanced cancer of the pancreas. 5FU was given for 7 days in a dose of 500 mg/m2 by continuous venous infusion over a 24-hour period and then followed by a dose of 170 mg/m2 for more than 28 days. Ten patients had no change including 1 patient with minor response, and 4 patients had disease progression. Serum CA19-9 levels were measured serially after chemotherapy in 13 of 14 evaluable patients. In 3 of 10 patients who showed high levels before treatment, serum CA19-9 levels were significantly decreasing after treatment.Keywords
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