Biochemical Changes Following Poisoning of Rats by Alphanaphthylthiourea
- 1 February 1946
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 61 (2) , 102-104
- https://doi.org/10.3181/00379727-61-15239p
Abstract
The intra-peritoneal injn. of 10 mg./kg. of alphanaphthylthiourea (ANTU) into rats caused a marked rise in blood sugar from an avg. value of 68 mg. % to 173 mg. % in 2.5 hrs. Liver glycogen values fell from a normal of 1.13% to 0.019%. ANTU-poisoned animals were unable to deposit liver glycogen. While these expts. demonstrate a disturbance in carbohydrate metabolism, they do not prove that death from ANTU is due to these changes. In rats, large doses of cysteine (1000 mg./kg.) afforded protection from death against 10 mg./kg. of ANTU.Keywords
This publication has 0 references indexed in Scilit: