High Arterial Pressure versus Humoral Factors in the Pathogenesis of the Vascular Lesions of Malignant Hypertension the Case for Pressure Alone

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Abstract
Neither the blood pressure nor a particular humoral factor, nor any other factor which might alter the microcirculation and vascular permeability, should be taken as the sole agent that causes hypertensive vascular disease. They should be considered as concurrent factors, of which the blood pressure is the primum movens as well as the final effector. The quantitative contribution of each of these factors, and particularly of vasoconstrictor hormones, might vary in the pathogenesis of vascular damage depending on the natural course of high blood pressure, the interference of other pathological processes, or upon the experimental procedure by which vascular damage was produced. [Dogs, rats, monkeys and man were studied.].

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