The Deposition of the Rare Earths in Bone

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Abstract
A controversy exists as to whether the rare-earth elements in bone tissue are retained by bone protein, or not. The present experiments in vivo and in vitro were carried out to ascertain the localization of 3 rare-earth elements, Y91, Ce144 and Tm170 in the bones of dogs after intraperitoneal injection. The rare-earth elements are deposited in vivo on highly mineralized non-growing surfaces of bone that are either resorbing or are inactive. In vitro, activity is retained by bone mineral and not by bone protein samples. The results are consistent with the conclusion that the rare-earth elements are absorbed onto bone mineral surfaces and are not taken up by the matrix of bone.