Spinal Subarachnoid Seeding from Glioblastoma Multiforme of the Brain Stem

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Abstract
Three children with glioblastoma multiforme of the brain stem were autopsied and all were found to have spinal subarachnoid seeding. The clinical courses of these patients were all rapid. Brain stem gliomas are rarely reported to seed along the spinal subarachnoid spaces, but the incidence of spinal subarachnoid seeding may actually be somewhat higher than is generally accepted. In the treatment of rapidly progressing brain stem gliomas, consideration should be given to possibly accompanying subarachnoid seeding.

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