Hemodynamic Effects of Selective Dopamine Receptor Agonists in the Rat and Dog
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 9 (5-6) , 889-912
- https://doi.org/10.3109/10641968709161456
Abstract
The availability of highly selective dopamine receptor agonists has allowed the characterization of the role of DA1 and DA2 receptors in the cardiovascular system. Fenoldopam (SK&F 82526) is a potent agonist at DA2 receptors, with much less agonist activity at the DA2 subtype or at alpha and beta adrenoceptors. In contrast, SK&F 89124 activates only the DA2 subtype. SK&F 85174, the N-allyl derivative of fenoldopam, retains potent DA1 agonist activity but also has moderately potent agonist activity at the DA2 receptor.Keywords
This publication has 24 references indexed in Scilit:
- Selective antagonism of the hypotensive effects of dopamine agonists in spontaneously hypertensive rats.Hypertension, 1986
- Peripheral dopamine receptor subtypes — a closer lookTrends in Pharmacological Sciences, 1985
- GANGLIONIC DOPAMINE RECEPTORS AS MEDIATORS OF THE INHIBITION OF NEUROGENIC VASOCONSTRICTION PRODUCED BY FENOLDOPAMJournal of Autonomic Pharmacology, 1985
- The DA1 receptor agonist fenoldopam (SK & F 82526) is also an α2-adrenoceptor antagonistEuropean Journal of Pharmacology, 1985
- Neuroinhibitory Effects of SK&F 85174, a Novel Dopamine Receptor AgonistJournal of Cardiovascular Pharmacology, 1985
- Propylbutyldopamine. Mechanism of blood pressure lowering in hypertensive patients.Hypertension, 1984
- 4-(Aminoalkyl)-7-hydroxy-2(3H)-indolones, a novel class of potent presynaptic dopamine receptor agonistsJournal of Medicinal Chemistry, 1983
- Propylbutyldopamine: hemodynamic effects in conscious dogs, normal human volunteers and patients with heart failure.Circulation, 1983
- Renal vasodilators and hypertensionDrug Development Research, 1982
- Dopamine — Clinical Uses of an Endogenous CatecholamineNew England Journal of Medicine, 1974