Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes
- 1 December 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 300 (5894) , 709-713
- https://doi.org/10.1038/300709a0
Abstract
Cosmid clones containing the human .gamma., .epsilon. and .alpha. H chain constant region genes and an .epsilon. pseudogene were isolated. All these genes have a switch sequence detectable by hybridization. Overlapping cosmids covering 2 separate regions of the genome were studied, and the gene order in each of these regions was found to be .gamma.-.gamma.-.epsilon.-.alpha.. This implies an evolutionary duplication in this multigene family involving .gamma., .epsilon. and .alpha. genes.Keywords
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