Escherichia coli mutants deficient in guanine-xanthine phosphoribosyltransferase
- 1 June 1976
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 126 (3) , 1141-1148
- https://doi.org/10.1128/jb.126.3.1141-1148.1976
Abstract
The purine phosphoribosyltransferases (PRTases) of E. coli were studied, and a mutant, defective in its ability to convert guanine and xanthine to their respective ribonucleotides, was isolated. The affected gene (gpt) lies between metD and proA and is 78.6% cotransducible with proA. This point mutant and a strain with a pro-lac deletion contain less than 2% of wild-type xanthine PRTase activity, yet still contain about 30% of wild-type guanine PRTase activity. The gpt gene is only 1 of at least 2 genes responsible for guanine PRTase activity in E. coli.This publication has 36 references indexed in Scilit:
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