TOXICOLOGIC AND IMMUNOLOGICAL EFFECTS OF SUBLETHAL DOSES OF CYCLOPIAZONIC ACID IN RATS

  • 1 May 1986
    • journal article
    • research article
    • Vol. 47  (5) , 1174-1177
Abstract
Effects of cyclopiazonic acid (CPA) on humoral immunity, cell-mediated immunity, weight gain, organ weights, clinical chemical and hematologic values, and gross and microscopic lesions were evaluated. Four groups of rats each containing 3 males and 3 females, were given 0, 0.1, 1, and 5 mg of CPA/kg of body weight intraperitoneally for 28 days. A dosage level of 5 mg/kg produced a significant (P < 0.05) decrease in weight gain. Rats given 0.1 or 1 mg of CPA/kg had a significant (P < 0.05) reduction in antibody titer against sheep RBC 5 days after injection. Microscopic lesions were limited to liver and kidneys and were characterized by vacuolated to granular hepatocyte cytoplasm and dilated renal convoluted tubules, many having pyknotic nuclei and scattered hyaline casts.