Avian Pancreatic Polypeptide Phase Shifts Hamster Circadian Rhythms When Microinjected into the Suprachiasmatic Region
- 24 February 1984
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 223 (4638) , 833-835
- https://doi.org/10.1126/science.6546454
Abstract
The suprachiasmatic nucleus has been identified tentatively as a circadian pacemaker. To examine the functional role of peptides found within suprachiasmatic neurons, avian pancreatic polypeptide and vasopressin were microinjected into the suprachiasmatic region. Avian pancreatic polypeptide, but not vasopressin, shifted the phase of the wheelrunning rhythm as a function of the time of its injection within the circadian cycle. Avian pancreatic polypeptide or a similar peptide may be one component of the neurochemical processes underlying entrainment to the light-dark cycle.Keywords
This publication has 29 references indexed in Scilit:
- Neuropeptide Y Distribution in the Rat BrainScience, 1983
- Role for Acetylcholine in Mediating Effects of Light on ReproductionScience, 1983
- Ventral lateral geniculate nucleus efferents to the rat suprachiasmatic nucleus exhibit avian pancreatic polypeptide‐like immunoreactivityJournal of Comparative Neurology, 1982
- Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptideNature, 1982
- Suprachiasmatic Stimulation Phase Shifts Rodent Circadian RhythmsScience, 1982
- The suprachiasmatic hypothalamic nuclei of the ratBehavioral and Neural Biology, 1980
- Serotonin neurons of the midbrain raphe: Ascending projectionsJournal of Comparative Neurology, 1978
- Suprachiasmatic Nucleus: Use of 14 C-Labeled Deoxyglucose Uptake as a Functional MarkerScience, 1977
- An autoradiographic study of the efferent connections of the ventral lateral geniculate nucleus in the albino rat and the catJournal of Comparative Neurology, 1974
- A retinohypothalamic projection in the ratJournal of Comparative Neurology, 1972