Bleomycin models. Haemin–acridines which bind to DNA and cause oxygen-dependent scission

1 January 1982

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 22,p. 1298-1300
https://doi.org/10.1039/c39820001298

Abstract

Haemin–acirdines intercalate into duplex DNA via the acridine moiety and, in the presence of reducing agents, cause oxygen dependent scission and show antileukemic properties analogous to the action of the glycopeptide antibiotic bleomycin.

Keywords

MODELS
ACRIDINES
HAEMIN
INTERCALATE
GLYCOPEPTIDE
ANALOGOUS
ANTILEUKEMIC
ANTIBIOTIC
ACIRDINES
MOIETY