Purification of Q Fever Rickettsiae by Density-Gradient Sedimentation
Open Access
- 1 September 1960
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 85 (3) , 314-318
- https://doi.org/10.4049/jimmunol.85.3.314
Abstract
Summary: A rapid method for isolation and purification of Q fever rickettsiae is described. It consists of differential centrifugation of homogenates of infected yolk sacs or chick embryo tissue in M/1 KCl followed by sedimentation in continuous linear sucrose or glycerin gradients. Adequate yields of electron microscopically pure rickettsiae were obtained.Keywords
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