Untersuchungen über das Zustandekommen der bösartigen Geschwülste. 1. Der Milchsäuregehalt der Gewebe.

Publisher Website
Google Scholar
Abstract
From the fact that lactic acid formed in tumor tissue can be found permeating the surrounding connective tissue, and apparently causing the morphological changes ordinarily found there, the writer believes that this may be in large part responsible for the breaking down of the barriers between the two. Such lactic acid, however, represents only a small portion of the total amount produced in the tumor. A considerable amount is carried away in the circulation. As regards its origin, while heightened sugar cleavage is a large factor, the lack of resynthesis may also play an appreciable part. To evaluate quantitatively the lactic acid production of a tissue, it would be necessary to know the part played by each of the foregoing factors. As regards the residual lactic acid found in tumor tissue, the writer found great fluctuations, but states that in general their bounds range about 100 % higher than those of normal tissues. To the extent that his results were obtained with human tumors, they are vitiated by the fact that estimation on them were delayed about 90 min. after removal, and control experiments on rat tumors showed that lactic acid content rapidly increased after excision of the tumor.

This publication has 0 references indexed in Scilit: