Vascular Endothelial Growth Factor Is Induced by the Inflammatory Cytokines Interleukin-6 and Oncostatin M in Human Adipose Tissue In Vitro and in Murine Adipose Tissue In Vivo
- 1 July 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 27 (7) , 1587-1595
- https://doi.org/10.1161/atvbaha.107.143081
Abstract
Objectives— It is believed that adipose tissue acts as an endocrine organ by producing inflammatory mediators and thereby contributes to the increased cardiovascular risk seen in obesity. A link be... Recent studies found that adipose tissue mass could be regulated through the vasculature. We show that the inflammatory cytokines IL-6 and OSM upregulate VEGF in human adipose tissue via JAK/STAT. ...This publication has 31 references indexed in Scilit:
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