Brain Monoamines in Guinea Pigs with Experimental Allergic Encephalitis

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Abstract
Guinea pigs were inoculated with encephalitogenic protein and concentrations of monoamines and acid metabolites of brains and spinal cords were determined. A reduction of contents of 5-hydroxytryptamine (5-HT) in brain and spinal cord specimens of animals affected by experimental allergic encephalitis (EAE) was demonstrable. The reduction was correlated to the severity of the symptoms of disease. There were no significant changes in concentrations of 5-hydroxyindoleacetic acid. These findings and observations of the effects of p-chlorophenylalanine, tryptophan, pargyline and lysergic acid diethylamide (LSD) indicate that the turnover of 5-HT in functioning neurons is not impaired. The results suggest that EAE causes loss of 5-HT transmitting neurons.

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