Microbial Degradation of Nicotine-N′-oxide I Degradation Products
- 1 August 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 42 (8) , 1455-1460
- https://doi.org/10.1080/00021369.1978.10863187
Abstract
Bacteria degrading nicotine-N′-oxide were isolated from tobacco leaves and soil of tobacco field. The bacterial metabolites from nicotine-N′-oxide were identified to be N′- methylmyosirune and 4′-keto-4′-(3-pyridyl)butylic acid, and four unidentified compounds were present. Accumulation of N′-methylmyosmine in the cultured medium reached 43%, in quantity of the initial substrate on the third day of culture. On the other hand, nicotine was far more slowly degraded by the same bacteria, and the first metabolite was identified to be 6-hydroxynicotine and the second to be 6-hydroxy-N′-methylmyosmine, suggesting that nicotine and its oxide are metabolized in different pathways.This publication has 14 references indexed in Scilit:
- The Absorption of Nicotine-1′-N-Oxide and its Reduction in the Gastro-Intestinal Tract in ManXenobiotica, 1973
- Formation of an intermediate N-oxide in the oxidative demethylation of N,N-dimethylaniline catalyzed by liver microsomesBiochemical and Biophysical Research Communications, 1964
- Microbial Resolution of dl-NicotineJournal of the agricultural chemical society of Japan, 1963
- Chemical and enzymic rearrangements of N,N-dimethyl amino acid oxidesBiochimica et Biophysica Acta, 1956
- Microbial Degradation of Nicotine and Nicotinic AcidJournal of the agricultural chemical society of Japan, 1955
- Degradation of Nicotine by Soil Bacteria1Journal of the American Chemical Society, 1954
- Mechanism of Microbial Degradation of NicotineScience, 1953
- The Chemistry of Tobacco Fermentation. I. Conversion of the Alkaloids. A. The Formation of 3-Pyridyl Methyl Ketone and of 2,3'-DipyridylJournal of the American Chemical Society, 1952
- Ultraviolet Absorption Spectra of Nicotine, Nornicotine and Some of Their DerivativesJournal of the American Chemical Society, 1949
- The Effect of Ultraviolet Radiation on NicotineJournal of the American Chemical Society, 1941