Dietary influences on 8-MOP plasma levels in PUVA patients with psoriasis

Abstract
The effect of diet on 8-MOP [methoxypsoralen] plasma levels was measured 3 times in 20 psoriasis patients treated with methoxsalen and UVA while fasting, after a low-fat breakfast and after a fat-rich breakfast. No significant differences were found between the maximal 8-MOP plasma levels in the fasting condition and the levels after the low-fat breakfast, both peaking 2 h after ingestion. After the fat-rich breakfast, the 8-MOP plasma levels were not only significantly lower at 2 h but also peaked later, reaching their at 3-4 h after intake. The drug should be given in a dietetically standardized way. This raises the question whether some cases of therapy resistance can be dietetically influenced.