Dietary influences on 8-MOP plasma levels in PUVA patients with psoriasis
- 1 November 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 105 (5) , 569-572
- https://doi.org/10.1111/j.1365-2133.1981.tb00801.x
Abstract
The effect of diet on 8-MOP [methoxypsoralen] plasma levels was measured 3 times in 20 psoriasis patients treated with methoxsalen and UVA while fasting, after a low-fat breakfast and after a fat-rich breakfast. No significant differences were found between the maximal 8-MOP plasma levels in the fasting condition and the levels after the low-fat breakfast, both peaking 2 h after ingestion. After the fat-rich breakfast, the 8-MOP plasma levels were not only significantly lower at 2 h but also peaked later, reaching their at 3-4 h after intake. The drug should be given in a dietetically standardized way. This raises the question whether some cases of therapy resistance can be dietetically influenced.This publication has 6 references indexed in Scilit:
- 8-MOP plasma levels in PUVA problem cases with psoriasisBritish Journal of Dermatology, 1979
- Serum concentration and phototoxic effect of methoxsalen in patients with psoriasisClinical Pharmacology & Therapeutics, 1979
- COMPARISON OF PHOTOCHEMOTHERAPY AND DITHRANOL IN THE TREATMENT OF CHRONIC PLAQUE PSORIASISPublished by Elsevier ,1979
- Plasma levels of 8-methoxypsoralen and phototoxicity studies during PUVA treatment of psoriasis with meladinin tabletsActa Dermato-Venereologica, 1978
- Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet LightNew England Journal of Medicine, 1974