Antigen-induced strain-specific autoantiidiotypic antibodies modulate the immune response to dextran B 512.

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Abstract
Sera from CBA and C57BL mice immunized against dextran B 512 eight or more days earlier contained mainly Ig[immunoglobulin]G antibodies that specifically suppressed development of plaque-forming cells against dextran in vitro. Suppression was not caused by antibodies against the .alpha. 1-6 epitope of dextran to any major extent. Sera from CBA mice (IgCH allotype j) suppressed plaque-forming cells from CBA mice and sera from C57BL mice (allotype b) inhibited plaques from C57BL and CBA/Ig-1b mice. Sera from dextran-tolerant mice or from mice that were genetic unresponders to dextran did not suppress plaque-forming cells. Thymus-independent and thymus-dependent forms of dextran induced the appearance of these autoantiidiotypic antibodies that can distinguish between anti-.alpha. 1-6 antibodies produced in mouse strains having different IgCH-locus-determined allotypes.