Disposition of oxazepam in relation to age, sex, and cigarette smoking

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Abstract
The kinetics of single 30-mg oral doses of oxazepam were determined in 22 male and nine female volunteers aged 20–86 years. Oxazepam plasma concentrations were measured in multiple plasma samples drawn during 36 h after each dose. Mean kinetic variables in males and females, respectively, were: elimination half-life, 7.5 and 8.5 h; volume of distribution, 0.96 and 1.17 l/kg; clearance, 1.48 and 1.70 ml/min/kg. Sex differences were not significant, nor were any of the kinetic variables significantly related to age. However, oxazepam clerance increased significantly with heavier cigarette smoking (r=0.48,ppp<0,01). Im Gegensatz zu anderen Benzodiazepinen beeinflussen die Rauchergewohnheiten die Kinetik des Oxazepam mehr als die alters- oder geschlechtsgebundenen Faktoren.