Serum zinc and retinol-binding protein in acne

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Abstract
The serum levels of Zn and retinol-binding protein (RBP) were determined in 173 patients with acne and compared with those of a control group. The RBP is a specific transport protein and its level in plasma reflects the amount of vitamin A available to the tissues. Patients with severe acne had lower levels of RBP than either patients with mild acne or healthy subjects of the same age. In the case of males with severe acne, the mean serum Zn level was significantly lower than that of the control group. No such difference was observed for girls. The observed condition of low levels of Zn and vitamin A in the serum of patients with severe acne may provide a rationale for the clinically good effect of oral Zn treatment.