Fundamental studies on physiological and pharmacological actions of L-ascorbate 2-sulfate. I. On the hypolipidemic effects.
- 1 January 1976
- journal article
- research article
- Published by Center for Academic Publications Japan in Journal of Nutritional Science and Vitaminology
- Vol. 22 (3) , 201-208
- https://doi.org/10.3177/jnsv.22.201
Abstract
The effects of L-ascorbate 2-sulfate (AAS) were studied on lipid metabolism in Triton-induced hyperlipemic mice, hypercholesterolemic and normal rats. In Triton-induced hyperlipemic mice, AAS (300 mg/kg) significantly decreased the serum cholesterol level, while L-ascorbate (AA, 175 mg/kg) was ineffective. In hypercholesterolemic rats fed 0.5% cholesterol diet, the consecutive administration of AAS decreased the level of serum cholesterol and liver triacylglycerols. AA only slightly affected these levels. Both AAS and AA prevented the increase in liver weight caused by cholesterol feeding. In normal rats, the administration of AAS over a 4 wk period decreased the level of serum cholesterol and liver triacylglycerols.This publication has 3 references indexed in Scilit:
- A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry, 1957
- Simple Rapid Microtechnic for Serum Total CholesterolAmerican Journal of Clinical Pathology, 1957
- The Inhibition of the Proteolytic Action of Pepsin by Sulfate-Containing PolysaccharidesGastroenterology, 1954