Oncogenic Activity of Adenovirus 12 in Thymectomized BALB/c and C3H/HeN Mice

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Abstract
Summary Newborn BALB/c and C3H HeN mice inoculated subcutaneously with human adenovirus 12 developed tumors only when thymectomized at birth. Tumors developed in 5 of 30 BALB/c and 3 of 18 C3H/HeN thymectomized mice. These results suggest that neonatally thymectomized animals may be useful in evaluation of the oncogenic potential of viruses which have not produced tumors when injected into non-thymectomized animals.

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