Effect of indomethacin on renal function in anaesthetized dogs

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Abstract
The inhibitory action of indomethacin administered as a single-dose injection (4 mg/kg) was examined under general anaesthesia in dogs, moderate volume expansion having been induced with physiological saline infusion. At 20 to 30 min after the administration of indomethacin, excretion of Na and water showed a fall of the same extent, GFR remaining stable and the effective plasma flow (CPAH) declining. RBF estimated by the86Rb method decreased from 411±96 ml/min/100 g to 292±±53 ml/min/100 g (p<0.01). This fall was coupled with an intrarenal redistribution of blood flow. While the cortical fraction of renal blood flow increased from 79% to 83.9% (p<0.001), its outer medullary fraction decreased from 17% to 13.2% (p<0.001) and its inner medullary fraction from 4.0% to 2.8% (p<0.05). The renal, primarily the medullary, vasculature is assumed on these grounds to be under the influence of a continuous secretion of prostaglandins which thus seem to be involved in the physiological control of intrarenal distribution of blood flow and of sodium and water excretion.

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