PRESENCE OF MAST-CELL PRECURSORS IN PERIPHERAL-BLOOD OF MICE DEMONSTRATED BY PARABIOSIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (6) , 1085-1088
Abstract
The presence of mast cell precursors in peripheral blood was examined. The beige C57BL/6 (bgJ/bgJ, Chediak-Higashi syndrome) mouse was parabiosed with the normal C57BL/6 mouse. Mast cells containing giant granules and originating in the beige partner appeared in the normal parabiont. A comparable proportion of normal-mouse-type mast cells developed in the beige parabiont as well. In spite of the low radiosensitivity of mature mast cells, irradiation of the normal parabiont reduced the proportion of normal mouse type mast cells appearing in the beige partner. The precursors of mast cells can apparently migrate through the bloodstream.