Requirement for CD8 β Chain in Positive Selection of CD8-Lineage T Cells
- 25 February 1994
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 263 (5150) , 1131-1133
- https://doi.org/10.1126/science.8108731
Abstract
CD8 is either an αα homodimer or an αβ heterodimer, although most peripheral CD8-lineage T cells express only the CD8αβ heterodimer. The physiological function of CD8β was elucidated with mice that were chimeric for the homozygous disruption of the CD8β gene. The CD8β -/- T cells developed normally to CD4 + CD8 + stage, but did not efficiently differentiate further, which resulted in few peripheral CD8 + T cells. The number of peripheral CD8 + T cells was restored by transfer of an exogenous CD8β gene into CD8β-deficient T cells. Thus, CD8β is necessary for the maturation of CD8 + T cells.Keywords
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