Homeostatic regulation of zinc absorption and endogenous losses in zinc-deprived men

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Abstract
The mechanisms involved in the homeostatic regulation of zinc were studied in five male subjects by using stable 70Zn as a marker. When dietary zinc was reduced from 85 to 12 /imol/d, adaptation was achieved by a mean (±SEM) reduction in urine zinc of 48 ± 7% and in fecal zinc of 46 ± 12% over 25 d in four subjects. The latter was caused by an increase in the efficiency of zinc absorption from 38 ± 3% to 93 ± 1% after 15 d of zinic deprivation and by a reduction in intestinal endogenous losses of zinc. In a fifth subject, who had some evidence of a resolving alcohol-induced hepatitis, urine and fecal zinc were reduced by 64% and 41%, respectively, in 15 d and zinc absorption increased from 46% to 93%. More information on adaptive responses is needed to enable current dietary recommendations to be reconsidered.