A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 1526-1528
- https://doi.org/10.1039/c39900001526
Abstract
Gold surfaces intended for surface plasmon resonance sensors have been derivatized with a flexible matrix composed of carboxymethylated dextran to provide fast and efficient coupling of proteins and other ligands at low concentrations using the principles of ionic pre-concentration; these hydrophilic and protein compatible hydrogel surfaces allow increased immobilization capacity as compared to monolayer based coatings, for applications in biospecific interaction analysis.Keywords
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