Antihepatotoxic Actions of Lignoids fromSchizandra chinensisFruits

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Abstract
The antihepatotoxic effects of twenty-three lignans, twenty-two from the fruits of Schizandra chinensis and one from the fruits of Kadsura japonica, were investigated utilizing carbon tetrachloride (CCl4)- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes as model systems. Prominent protective actions were found with wuweizisu C and schisantherin D in CCl4-treated cultures, and deoxygomisin A, gomisin N, wuweizisu C, gomisin C and schisantherin D were effective in preventing GalN-induced cell damage. Structure-activity relationship suggests that the methylenedioxy group of the dibenzocyclooctane skeleton may play an important role in antihepatotoxic activity. 1 Part 11 in the Tohoku University series on Liver-protective drugs. Also Part 60 on the validity of the Oriental medicines.

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