Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation
- 29 July 2002
- journal article
- Published by Springer Nature in Oncogene
- Vol. 21 (33) , 5088-5096
- https://doi.org/10.1038/sj.onc.1205668
Abstract
The E6 proteins from the high-risk human papillomavirus (HPV) types have previously been shown to target a number of PDZ domain-containing proteins for proteasome-mediated degradation. These include the hDlg tumour suppressor and the MAGI-1 protein. In this study we show that high-risk HPV E6 proteins also target the related MAGI-2 and MAGI-3 proteins for degradation. Moreover, we show that the interaction is specific to one PDZ domain, and that co-expression of this domain can protect each of the full-length MAGI proteins from E6-mediated degradation. These data provide clear indicators for the potential design of compounds that could specifically inhibit the interaction of oncogenic HPV E6 proteins with an important class of target proteins.Keywords
This publication has 51 references indexed in Scilit:
- HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradationOncogene, 2001
- Identification of mNET1 as a Candidate Ligand for the First PDZ Domain of MAGI-1Biochemical and Biophysical Research Communications, 2001
- The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C TerminusJournal of Biological Chemistry, 2001
- Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteinsOncogene, 2000
- MAGI-1 Interacts with β-Catenin and Is Associated with Cell–Cell Adhesion StructuresBiochemical and Biophysical Research Communications, 2000
- HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligaseOncogene, 2000
- Localization of membrane-associated guanylate kinase (MAGI)-1/BAI-associated protein (BAP) 1 at tight junctions of epithelial cellsOncogene, 1999
- PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membraneJournal of Clinical Investigation, 1999
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTENCell, 1998
- Crystal structure of a PDZ domainNature, 1996