Structures of RNA Switches: Insight into Molecular Recognition and Tertiary Structure
- 5 February 2007
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 46 (8) , 1212-1219
- https://doi.org/10.1002/anie.200604163
Abstract
RNA switches (riboswitches) have important functions in gene regulation. They comprise an aptamer domain, which is responsible for ligand binding, and an expression platform that transmits the ligand‐binding state of the aptamer domain through a conformational change. Riboswitches can regulate gene expression either at the level of transcription or translation, and it has been proposed that riboswitch mechanisms are even used to regulate the processing of mRNA. This Minireview summarizes the current understanding of the structures and mode of action of RNA switches, with particular focus on secondary and tertiary interactions, which stabilize the global RNA structure and thus determine the function of the aptamer domain.Keywords
This publication has 39 references indexed in Scilit:
- Sensing Small Molecules by Nascent RNACell, 2002
- Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expressionNature, 2002
- Do mRNAs act as direct sensors of small molecules to control their expression?Proceedings of the National Academy of Sciences, 2001
- A conserved RNA structure ( thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteriaProceedings of the National Academy of Sciences, 2001
- Adaptive Recognition by Nucleic Acid AptamersScience, 2000
- Oligonucleotide aptamers that recognize small moleculesPublished by Elsevier ,1999
- RNA aptamers to the adenosine moiety of S-adenosyl methionine: structural inferences from variations on a theme and the reproducibility of SELEXNucleic Acids Research, 1997
- In vitro evolution of nucleic acidsCurrent Opinion in Structural Biology, 1994
- All you wanted to know about SELEXMolecular Biology Reports, 1994
- In vitro selection of RNA molecules that bind specific ligandsNature, 1990