1α-Hydroxy Derivative of Vitamin D 3 : A Highly Potent Analog of 1α,25-Dihydroxyvitamin D 3
- 13 April 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 180 (4082) , 190-191
- https://doi.org/10.1126/science.180.4082.190
Abstract
The 1α-hydroxy derivative of vitamin D3 has been chemically synthesized and tested for its biological activity. This analog has comparable biological activity on a weight basis to 1,25-dihydroxyvitamin D3 in the stimulation of intestinal calcium transport and bone calcium mobilization in normnal and anephric rats. Because the 1α-hydroxy derivative is synthesized from cholesterol, it is easier and less expensive to prepare than 1α,25-dihydroxy derivative, making it attractive as a drug in the treatment of renal osteodystrophy and hypopara-thyroidism.Keywords
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