Lymphocyte Transformation in the Diagnosis of Congenital Toxoplasma Infection

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Abstract
Approximately 3300 infants born each year in the United States are congenitally infected with toxoplasma.1 Most are asymptomatic during the neonatal period, but many will subsequently have adverse sequelae.2 Treatment during infancy may reduce the subsequent development of adverse sequelae; however, difficulty in establishing the diagnosis of congenital toxoplasma infection at that time has hindered studies to determine the efficacy of such treatment. Thus, new methods are needed to establish the diagnosis of congenital toxoplasma infection during the first year of life. Current diagnostic methods are not sufficiently sensitive (e.g., tests for IgM toxoplasma antibodies in blood from infants), are . . .