CRF-41 Stimulates the Release of β-Lipotrophin and β-Endorphin in Normal Human Subjects

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Abstract
A prompt rise in circulating immunoreactive N- and C-terminal lipotrophin (LPH) accompanied the increase in ACTH when 100 µg CRF-41 was given to 6 normal male subjects. Chromatography of the basal and peak 15-min values showed that there was an equimolar increase in β-LPH and β-endorphin. to cause parallel release of ACTH, β-endorphin and β-LPH from the pro-opiocortin precursor.