A controlled study of pneumococcal polysaccharide vaccine in systemic lupus erythematosus
Open Access
- 1 December 1979
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 22 (12) , 1321-1325
- https://doi.org/10.1002/art.1780221201
Abstract
The immunogenicity and potential for disease modification of pneumococcal polysaccharide vaccine in systemic lupus erythematosus were evaluated in a controlled, double‐blind study. Forty patients were randomly chosen to receive an intramuscular injection of either vaccine or placebo. Changes in mean antibody concentrations (nanograms antibody nitrogen per milliliter serum) to 12 type‐specific pneumococcal capsular antigens from prevaccination to one month after vaccination were 177 to 1045 in the vaccine (P < 0.001) and 164 to 153 in the placebo‐treated patients. In the month after vaccination, neither vaccine nor placebo‐treated patients had a significant change in lupus disease activity as assessed by a composite clinical, laboratory, and serologic index. We conclude that patients with systemic lupus erythematosus can be successfully immunized with pneumococcal vaccine without detectable alterations of the underlying disease.This publication has 22 references indexed in Scilit:
- Failure of Pneumococcal Vaccine in Children with Sickle-Cell DiseaseNew England Journal of Medicine, 1979
- Mortality in lupus nephritisArthritis & Rheumatism, 1979
- Impaired Antibody Response to Pneumococcal Vaccine after Treatment for Hodgkin's DiseaseNew England Journal of Medicine, 1978
- Antibody Response to Capsular Polysaccharide Vaccine of Streptococcus pneumoniae in Patients with Nephrotic SyndromeThe Journal of Infectious Diseases, 1978
- Computer analysis of factors influencing frequency of infection in systemic lupus erythematosusArthritis & Rheumatism, 1978
- IMMUNE RESPONSE AFTER SPLENECTOMYThe Lancet, 1978
- Polyvalent Pneumococcal-Polysaccharide Immunization of Patients with Sickle-Cell Anemia and Patients with SplenectomyNew England Journal of Medicine, 1977
- Pneumococcal Infection and Pneumococcal VaccineNew England Journal of Medicine, 1977
- Incidence of infection in systemic lupus erythematosusArthritis & Rheumatism, 1974
- Decreased 19S antibody response to bacterial antigens in systemic lupus erythematosusJournal of Clinical Investigation, 1969