A Heretofore Unreported Agglutinable Human Blood Factor and Its Possible Relationship to Blackwater Fever

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Abstract
Summary It appears that a new human agglutinable blood factor has been demonstrated by the use of chimpanzee-immune serum developed in rabbits. The presence in 97 per cent of all healthy white group O individuals and 97.4 per cent of all healthy group O negroes studied strongly suggested that it is not associated with the AB, MN, Rh-Hr, or P systems. While we are not certain as to the usefulness of this factor it appears from previous work that its absence is intimately associated with the etiology of blackwater fever. It is possible that this factor may explain the unaccounted for reactions following the transfusion of compatible bloods of both AB group and Rh type.