A SYNTHETIC SUBSTITUTE FOR EPHEDRINE

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Abstract
The success of ephedrine in the treatment of asthma and allied conditions has created a demand for the drug which encourages the search for a more easily available source or, failing this, a cheaper but effective substitute. These considerations, as we have stated elsewhere,1led us into an unsuccessful attempt to obtain ephedrine from the several varieties of the plant ephedra, which grow in abundance on our California deserts and are closely related to ma huang or theEphedra vulgarisof China. Failure here caused us to consider the synthesis of an effective substitute. Ephedrine itself has been synthesized and is on the market, but the method of synthesis is difficult and expensive and therefore unsuitable for our purposes. As a result of these and other considerations which will be discussed later, Alles, working in our laboratory, synthesized a phenylethanolamine on which he has recently reported.2The following

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