Procholeragenoid: An Aggregated Intermediate in the Formation of Choleragenoid
Open Access
- 1 October 1971
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 107 (4) , 1043-1051
- https://doi.org/10.4049/jimmunol.107.4.1043
Abstract
A high molecular weight polymer, designated “procholeragenoid,” is an intermediate in the heat-mediated conversion of the cholera exo-enterotoxin, choleragen, to the natural toxoid, choleragenoid. The demonstration of this polymer offers an explanation for the conversion of the toxin, ca. 90,000 m.w., to the antigenically identical toxoid, ca. 60,000 m.w., without apparent loss of a fragment. Isolated procholeragenoid has little residual toxicity and is immunogenic for mice.Keywords
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