Pharmacokinetic–Pharmacodynamic Modeling of the Effectiveness and Safety of Buprenorphine and Fentanyl in Rats
Open Access
- 4 October 2007
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 25 (1) , 183-193
- https://doi.org/10.1007/s11095-007-9440-z
Abstract
Respiratory depression is a serious and potentially life-threatening side-effect of opioid therapy. The objective of this investigation was to characterize the relationship between buprenorphine or fentanyl exposure and the effectiveness and safety outcome in rats.Keywords
This publication has 41 references indexed in Scilit:
- Animal-to-Human Extrapolation of the Pharmacokinetic and Pharmacodynamic Properties of BuprenorphineClinical Pharmacokinetics, 2007
- Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of the Respiratory-Depressant Effect of Buprenorphine and Fentanyl in RatsThe Journal of Pharmacology and Experimental Therapeutics, 2006
- Population analysis of a 24‐h paclitaxel infusion in advanced endometrial cancer: a gynaecological oncology group studyBritish Journal of Clinical Pharmacology, 2006
- BuprenorphineAnnals of Emergency Medicine, 2004
- Book Review: Palliative care: an Oxford core textPalliative Medicine, 2003
- The minimum effective concentration of opioids: A revisitation with patient controlled analgesia fentanylRegional Anesthesia & Pain Medicine, 2000
- Adverse Effects of Opioid Agonists and Agonist-Antagonists in AnaesthesiaDrug Safety, 1998
- Post-operative intravenous continuous analgesia: comparison of buprenorphine, fentanyl and nalbuphineEuropean Journal of Anaesthesiology, 1996
- Electroencephalographic Quantitation of Opioid EffectAnesthesiology, 1991
- Intrathecal Methadone and Morphine for Postoperative AnalgesiaAnesthesiology, 1989