In vivo p53 function is indispensable for DNA damage‐induced apoptotic signaling in Drosophila
Open Access
- 30 July 2003
- journal article
- Published by Wiley in FEBS Letters
- Vol. 550 (1-3) , 5-10
- https://doi.org/10.1016/s0014-5793(03)00771-3
Abstract
P53 is a representative tumor suppressor whose dysfunction is a major cause of human cancer syndrome. Here we isolated flies lacking Dmp53, which encodes the single Drosophila orthologue of mammalian p53 family. Dmp53 null mutants well developed into adults, only displaying mild defects in longevity and fertility. However, genomic stability and viability of Dmp53 mutants dramatically decreased upon ionizing irradiation. Moreover, mutating Dmp53 abolished irradiation‐induced apoptosis and reaper induction. These results indicate that Dmp53 is a central component of DNA damage‐dependent apoptotic signaling.Keywords
This publication has 19 references indexed in Scilit:
- Decision making by p53: life, death and cancerCell Death & Differentiation, 2003
- Chk2 regulates irradiation-induced, p53-mediated apoptosis in DrosophilaProceedings of the National Academy of Sciences, 2002
- Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanismsNature Cell Biology, 2002
- Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in DrosophilaGene, 2001
- DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2Science, 2000
- Drosophila p53 Binds a Damage Response Element at the reaper LocusCell, 2000
- Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53Cell, 2000
- A novel form of Epstein-Barr virus latency in normal B cells in vivoCell, 1995
- WAF1, a potential mediator of p53 tumor suppressionCell, 1993
- Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other NeoplasmsScience, 1990