Studies on experimental autoimmune thymitis in guinea-pigs.

  • 1 October 1969
    • journal article
    • Vol. 5  (4) , 319-40
Abstract
Normal and thymectomized outbred guinea-pigs were immunized with extracts of calf thymus, calf skeletal muscle or calf heart muscle emulsified in Freund's complete adjuvant. Immunization with either thymus or skeletal muscle produced a significant incidence of thymitis and a partial neuromuscular block in contrast to control animals either untreated or injected with an extract of calf lymph node or saline in Freund's complete adjuvant. The incidence of thymitis and partial neuromuscular block in animals that were injected with an extract of calf heart muscle in Freund's complete adjuvant was found not to be significant when compared to the control animals.