DNA Microarrays in Herbal Drug Research
Open Access
- 1 January 2006
- journal article
- website
- Published by Wiley in Evidence-Based Complementary and Alternative Medicine
- Vol. 3 (4) , 447-457
- https://doi.org/10.1093/ecam/nel075
Abstract
Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.Keywords
Funding Information
- Council of Scientific and Industrial Research, India
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