Low-Density Lipoprotein Cholesterol and the Risk of Dementia With Stroke

Open Access
Publisher Website
Google Scholar
Abstract
Vascular dementia is considered the second major cause of dementia after Alzheimer disease in Western populations.1 While the role of coincident vascular disease in patients with Alzheimer disease has received attention,2 the origin of vascular dementia remains unclear. Previously we found that an apolipoprotein E ∊4 (APOE ∊4) allele increased the risk of dementia with stroke in a population-based case-control investigation.3APOE could influence the pathogenesis of dementia with stroke through its effects on lipid metabolism and atherosclerosis,4 but the relationship between lipids and the risk of dementia in the presence or absence of the APOE ∊4 allele has not been investigated. Plasma lipids and lipoprotein fractions were studied in a multiethnic elderly population to test the hypothesis that dyslipidemia could be an independent risk factor for the development of dementia with stroke.