Abortion May Sensitize the Mother to HLA Antigens

Abstract
The incidence of cytotoxic antibodies in relation to abortion histories was analyzed in sera from 474 nulliparous pregnant women. In patients with previous spontaneous abortions, there is a higher incidence of positive sera than in primigravidae. Patients with 2 or more prior abortions show a greater incidence of cytotoxic activity in their sera than women who have had only 1 abortion.