NEW EMBO MEMBERS' REVIEW: Lysosomal cysteine proteases: facts and opportunities
Top Cited Papers
Open Access
- 3 September 2001
- journal article
- review article
- Published by Springer Nature in The EMBO Journal
- Vol. 20 (17) , 4629-4633
- https://doi.org/10.1093/emboj/20.17.4629
Abstract
From their discovery in the first half of the 20th century, lysosomal cysteine proteases have come a long way: from being the enzymes non‐selectively degrading proteins in lysosomes to being those responsible for a number of important cellular processes. Some of the features and roles of their structures, specificity, regulation and physiology are discussed.Keywords
This publication has 41 references indexed in Scilit:
- The cystatins: Protein inhibitors of cysteine proteinasesPublished by Wiley ,2001
- Triggering of apoptosis by cathepsinsCell Death & Differentiation, 2001
- A lysosomal protease enters the death scene.Journal of Clinical Investigation, 2001
- Cathepsin L deficiency as molecular defect offurless:hyperproliferation of keratinocytes and pertubation of hair follicle cyclingThe FASEB Journal, 2000
- THE LYSOSOMAL CYSTEINE PROTEASESAnnual Review of Biophysics, 1999
- Crystal structure of porcine cathepsin H determined at 2.1 å resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase functionStructure, 1998
- Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K DeficiencyScience, 1996
- Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain‐like cysteine protease and its propeptideFEBS Letters, 1996
- Mutations in the Gene Encoding Cystatin B in Progressive Myoclonus Epilepsy (EPM1)Science, 1996
- A sound basis for pH-dependent kinetic studies on enzymesProtein Engineering, Design and Selection, 1994