SODIUM DIPHENYL HYDANTOINATE IN TREATMENT OF CONVULSIVE SEIZURES
- 1 December 1939
- journal article
- other
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 42 (6) , 1053-1058
- https://doi.org/10.1001/archneurpsyc.1939.02270240091005
Abstract
Sodium diphenyl hydantoinate has been used at the neurologic clinic of the Boston City Hospital for the past two years. During this time we have administered the drug to more than 350 patients. A detailed report of the therapeutic results in 142 of these patients has been previously made,1and the statistics on the entire series up to date are now in the press. It is the purpose of this communication to give our opinion regarding the regulation of the dose and the treatment and prevention of toxic reactions. In an attempt to evaluate the therapeutic efficiency of sodium diphenyl hydantoinate, it was thought advisable to use the drug only with patients who had received other forms of therapy, such as phenobarbital, bromides, a ketogenic diet, low fluid intake and surgical procedures and had not been relieved of their attacks. For the vast majority of our patients phenobarbital, sometimesKeywords
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