Cellular and Molecular Aspects of Antigen Processing and the Function of Class II MHC Molecules
- 1 May 1993
- journal article
- review article
- Published by American Thoracic Society in American Journal of Respiratory Cell and Molecular Biology
- Vol. 8 (5) , 461-467
- https://doi.org/10.1165/ajrcmb/8.5.461
Abstract
Antigen processing is the conversion of native antigen molecules into short peptides that can then bind to major histocompatibility complex (MHC) molecules. Class II MHC (MHC-II) molecules target to endocytic compartments, where they bind peptides that are produced by internalization of extracellular antigens and subsequent antigen catabolism. The resulting peptide-MHC complexes are displayed on the surface of antigen-presenting cells for recognition by T cells. Thus, MHC-II molecules first serve as peptide receptors that rescue peptides from total lysosomal degradation and transport them to the plasma membrane; the MHC-II molecules then form a composite peptide-MHC-II determinant that is recognized by the T cell receptor. Recent work has begun to clarify the molecular events and transport mechanisms that govern antigen processing.Keywords
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