Predisposition to Renal Cell Carcinoma Due to Alteration of a Cancer Susceptibility Gene
- 27 March 1992
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 255 (5052) , 1693-1695
- https://doi.org/10.1126/science.1553556
Abstract
A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.Keywords
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