Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis
- 15 July 2011
- journal article
- timeline
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 11 (8) , 551-558
- https://doi.org/10.1038/nri3020
Abstract
Labelling antigen-specific T cells with peptide–MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.Keywords
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