Transient Expression of CD20 Antigen (Pan B Cell Marker) in Activated Lymph Node T Cells
- 1 June 1996
- journal article
- Published by Wiley in Microbiology and Immunology
- Vol. 40 (6) , 467-471
- https://doi.org/10.1111/j.1348-0421.1996.tb01096.x
Abstract
In contrast to the case of peripheral T cells, the surface expression of CD20 antigen and the expression of CD20 mRNA in monkey lymph node (LN) T cells underwent a noticeable increase when they were cultured with mitogen and interleukin-2 (IL-2). To confirm in vivo regulation of CD20 expression during the activation of LN T cells, we examined LNs derived from monkeys experimentally inoculated with simian immunodeficiency virus (SIV). Significant expression of CD20 antigen was detected in the T cells of the LNs at the stage of lymphadenopathy. These findings suggest that lymphocyte activation in the LNs induced expression of the CD20 molecule in some T cells.Keywords
This publication has 19 references indexed in Scilit:
- Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.The Journal of cell biology, 1993
- Cd20 (pan‐B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytesCytometry, 1993
- Importance of the nef gene for maintenance of high virus loads and for development of AIDSCell, 1991
- Heterogeneity in the B1 (CD20) cell surface molecule expressed by human B-lymphocytesMolecular Immunology, 1988
- Functional characterization of an antigen involved in an early step of T-cell activation.Proceedings of the National Academy of Sciences, 1987
- Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens.The Journal of Experimental Medicine, 1986
- Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytesEuropean Journal of Immunology, 1986
- B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation.Journal of Clinical Investigation, 1984
- Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNANucleic Acids Research, 1984
- Expression of cell surface markers after human B lymphocyte activation.Proceedings of the National Academy of Sciences, 1981