Roles of Interleukin‐6 in Activation of STAT Proteins and Recruitment of Neutrophils duringEscherichia coliPneumonia
Open Access
- 1 February 2006
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 193 (3) , 360-369
- https://doi.org/10.1086/499312
Abstract
Interleukin (IL)–6 concentrations are positively associated with the severity of pneumonia, and this cytokine is essential to surviving experimentalKeywords
This publication has 64 references indexed in Scilit:
- Stat3 regulates genes common to both wound healing and cancerOncogene, 2005
- Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxinAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2004
- Acute Phase Reactants and Cytokine Levels in Unilateral Community-Acquired PneumoniaRespiration, 2003
- Nuclear Translocation of Phosphorylated STAT3 Is Essential for Vascular Endothelial Growth Factor-induced Human Dermal Microvascular Endothelial Cell Migration and Tube FormationJournal of Biological Chemistry, 2003
- STATs: transcriptional control and biological impactNature Reviews Molecular Cell Biology, 2002
- Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and AdhesionJournal of Biological Chemistry, 2001
- IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.Journal of Clinical Investigation, 1998
- Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice.Journal of Clinical Investigation, 1996
- Neutralization of Macrophage Inflammatory Protein-2 Attenuates Neutrophil Recruitment and Bacterial Clearance in Murine Klebsiella PneumoniaThe Journal of Infectious Diseases, 1996
- Impaired immune and acute-phase responses in interleukin-6-deficient miceNature, 1994